Oddly most of the manga I've read have been biographies of comics creators. Most recently, I made my way through the tome The Osamu Tezuka Story: A Life in Manga and Anime. Tezuka was a uniquely driven creator who lived a sheltered life.
His series Black Jack, is a fun adventure story like none I've ever read and also makes the most of his medical background. The art is beautiful, but after reading his biography I wonder how much of it was actually drawn by his assistants?